Article
Structural insight into the specificity of the B3 DNA-binding domains provided by the co-crystal structure of the C-terminal fragment of BfiI restriction enzyme.
Nucleic acids research - 1 Apr 2014
Golovenko Dmitrij, Manakova Elena, Zakrys Linas, Zaremba Mindaugas, Sasnauskas Giedrius, Gražulis Saulius, Siksnys Virginijus
Abstract excerpt
The B3 DNA-binding domains (DBDs) of plant transcription factors (TF) and DBDs of EcoRII and BfiI restriction endonucleases (EcoRII-N and BfiI-C) share a common structural fold, classified as the DNA-binding pseudobarrel. The B3 DBDs in the plant TFs recognize a diverse set of target sequences. The only available co-crystal structure of the B3-like DBD is that of EcoRII-N (recognition sequence 5'-CCTGG-3'). In...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.