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Article

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2014

Kuhn Misty L, Prachi Prachi, Minasov George, Shuvalova Ludmilla, Ruan Jiapeng, Dubrovska Ievgeniia, Winsor James, Giraldi Monica, Biagini Massimiliano, Liberatori Sabrina, Savino Silvana, Bagnoli Fabio, Anderson Wayne F, Grandi Guido

Abstract excerpt

Despite the global medical needs associated with Staphylococcus aureus infections, no licensed vaccines are currently available. We identified and characterized a protein annotated as an epidermin leader peptide processing serine protease (EpiP), as a novel S. aureus vaccine candidate. In addition, we determined the structure of the recombinant protein (rEpiP) by X-ray crystallography. The crystal structure...

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Identifiers

PMID: 24421400
DOI: 10.1096/fj.13-241737
PMCID: PMC3963019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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