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Article

The involvement of ADAMTS-5 genetic polymorphisms in predisposition and diffusion tensor imaging alterations of lumbar disc degeneration.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 May 2014

Wu Nan, Chen Jun, Liu Hao, Zhao Luo, Liu Sen, Liu Jiaqi, Su Xinlin, Wu Wenliang, Cong Jin, Qiu Guixing, Wu Zhihong

Abstract excerpt

PURPOSE: Low back pain is a global health problem in which more than 40% is caused by lumbar intervertebral disc degeneration (LDD). ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs-5) was shown to be involved in LDD by functional analyses. To identify whether there is an association between ADAMTS-5 and LDD, and what is the contribution of ADAMTS-5 genetic polymorphisms to MD (Mean...

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PMID: 24415654
DOI: 10.1002/jor.22582

Genes

IVD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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