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Article

A longitudinal population-based study identifies THBS2 as a susceptibility gene for intervertebral disc degeneration.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Sept 2024

Deguchi Tsuyoshi, Hashizume Hiroshi, Terao Chikashi, Nakajima Masahiro, Teraguchi Masatoshi, Yamada Hiroshi, Tanaka Sakae, Yoshimura Noriko, Yoshida Munehito, Ikegawa Shiro

Abstract excerpt

PURPOSE: Intervertebral disc degeneration (IDD) is a common degenerative disease associated with ageing. Additionally, IDD is recognized as one of the leading causes of low back pain and disability in the working-age population and is the first step in the process leading to degenerative spinal changes. However, the genetic factors and regulatory mechanisms of IDD remain unknown. Therefore, we selected eight...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38918228
DOI: 10.1007/s00586-024-08152-6

Genes

THBS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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