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Association betweenADAMTS-4gene polymorphism and lumbar disc degeneration in Chinese Han population

24 Oct 2015

Abstract excerpt

Low back pain (LBP) is a common health problem and many LBP are caused by lumbar disc degeneration (LDD). ADAMTS-4 (a disintegrin and metalloprotease with thrombospondin motifs-4), also known as aggrecanse-1, plays a core role in degeneration of extracellular matrix in LDD. To investigate the association between ADAMTS-4 genetic polymorphism and LDD, we genotyped SNPs in and around ADAMTS-4. We recruited 482...

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PMID: 26495885
DOI: 10.1002/jor.23081

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