Article
L-histidine decarboxylase and Tourette's syndrome.
The New England journal of medicine - 20 May 2010
Ercan-Sencicek A Gulhan, Stillman Althea A, Ghosh Ananda K, Bilguvar Kaya, O'Roak Brian J, Mason Christopher E, Abbott Thomas, Gupta Abha, King Robert A, Pauls David L, Tischfield Jay A, Heiman Gary A, Singer Harvey S, Gilbert Donald L, Hoekstra Pieter J, Morgan Thomas M, Loring Erin, Yasuno Katsuhito, Fernandez Thomas, Sanders Stephan, Louvi Angeliki, Cho Judy H, Mane Shrikant, Colangelo Christopher M, Biederer Thomas, Lifton Richard P, Gunel Murat, State Matthew W
Abstract excerpt
Tourette's syndrome is a common developmental neuropsychiatric disorder characterized by chronic motor and vocal tics. Despite a strong genetic contribution, inheritance is complex, and risk alleles have proven difficult to identify. Here, we describe an analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.