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Article

The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2014

Karsy Michael, Albert Ladislau, Murali Raj, Jhanwar-Uniyal Meena

Abstract excerpt

Glioblastoma (GBM) is the most common primary brain tumor in adults and demonstrates a 1-year median survival time. Codon-specific hotspot mutations of p53 result in constitutively active mutant p53, which promotes aberrant proliferation, anti-apoptosis, and cell cycle checkpoint failure in GBM....

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Identifiers

PMID: 24399651
DOI: 10.1007/s13277-013-1601-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24399651-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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