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Article

Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Shih Yu-Ru V, Hwang YongSung, Phadke Ameya, Kang Heemin, Hwang Nathaniel S, Caro Eduardo J, Nguyen Steven, Siu Michael, Theodorakis Emmanuel A, Gianneschi Nathan C, Vecchio Kenneth S, Chien Shu, Lee Oscar K, Varghese Shyni

Abstract excerpt

Synthetic matrices emulating the physicochemical properties of tissue-specific ECMs are being developed at a rapid pace to regulate stem cell fate. Biomaterials containing calcium phosphate (CaP) moieties have been shown to support osteogenic differentiation of stem and progenitor cells and bone tissue formation. By using a mineralized synthetic matrix mimicking a CaP-rich bone microenvironment, we examine a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24395775
DOI: 10.1073/pnas.1321717111
PMCID: PMC3903237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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