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Article

Noninvasive prenatal detection of fetal trisomy 18 by epigenetic allelic ratio analysis in maternal plasma: Theoretical and empirical considerations.

Clinical chemistry - 1 Dec 2006

Tong Yu K, Ding Chunming, Chiu Rossa W K, Gerovassili Ageliki, Chim Stephen S C, Leung Tak Y, Leung Tse N, Lau Tze K, Nicolaides Kypros H, Lo Y M Dennis

Abstract excerpt

BACKGROUND: The discovery of cell-free fetal DNA in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. However, the use of maternal plasma fetal DNA for the direct detection of fetal chromosomal aneuploidies has not been reported. We postulate that the aneuploidy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17040955
DOI: 10.1373/clinchem.2006.076851

Genes

SERPINB5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17040955-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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