Article
Molecular strategies to replace the structural metal site in the prokaryotic zinc finger domain.
Biochimica et biophysica acta - 1 Mar 2014
Baglivo Ilaria, Palmieri Maddalena, Rivellino Alessia, Netti Fortuna, Russo Luigi, Esposito Sabrina, Iacovino Rosa, Farina Biancamaria, Isernia Carla, Fattorusso Roberto, Pedone Paolo Vincenzo, Malgieri Gaetano
Abstract excerpt
The specific arrangement of secondary elements in a local motif often totally relies on the formation of coordination bonds between metal ions and protein ligands. This is typified by the ~30 amino acid eukaryotic zinc finger motif in which a β-sheet and an α-helix are clustered around a zinc ion by various combinations of four ligands. The prokaryotic zinc finger domain (found in the Ros protein from...
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