Article
Beyond copper: examining the significance of His-mutations in mycobacterial GroEL1 HRCT for Ni(II) complex stability and formation.
Dalton transactions (Cambridge, England : 2003) - 16 Apr 2024
Rola Anna, Kola Arian, Valensin Daniela, Palacios Oscar, Capdevila Merce, Gumienna-Kontecka Elżbieta, Potocki Sławomir
Abstract excerpt
Recently, we have studied the coordination chemistry of the Cu(II)-histidine-rich C-terminal tail (HRCT) complex of the mycobacterial GroEL1 protein. The structure of this domain differs significantly compared to the well-known methionine-glycine-rich GroEL chaperonin - it was predicted that mycobacterial GroEL1 could play a significant role in the metal homeostasis of Mycobacteria, especially copper. However, we...
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