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Article

Conceptual Framework for Cutting the Pancreatic Cancer Fuel Supply

14 Aug 2012

Abstract excerpt

Pancreatic ductal adenocarcinoma (a.k.a. pancreatic cancer) remains one of the most feared and clinically challenging diseases to treat despite continual improvements in therapies. The genetic landscape of pancreatic cancer shows near ubiquitous activating mutations of KRAS, and recurrent inactivating mutations of CDKN2A, SMAD4, and TP53. To date, attempts to develop agents to target KRAS to specifically kill...

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PMID: 22896695
DOI: 10.1158/1078-0432.ccr-12-0041

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