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Article

The recently suggested intestinal cancer stem cell marker<i>DCLK1</i>is an epigenetic biomarker for colorectal cancer

2 Jan 2014

Abstract excerpt

Recently, Dclk1 expression was identified to be an intestinal cancer stem cell specific biomarker in mouse models, implicating a potential role for targeting the DCLK1-postive cancer cells as a treatment for colorectal cancer. Using quantitative methylation specific PCR (qMSP) we here demonstrated that the DCLK1 promoter is hypermethylated in the vast majority of colorectal cancers (134/164; 82%), with no...

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PMID: 24384857
DOI: 10.4161/epi.27582

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