Article
Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.
British journal of haematology - 1 Jan 2014
Dewamitta Sita R, Joseph Chacko, Purton Louise E, Walkley Carl R
Abstract excerpt
Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs....
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