Genomic correlations for clinical outcomes in HER2-positive advanced gastric cancers treated using trastuzumab-based therapy

Abstract excerpt

<title>Abstract</title> <p>Purpose Although trastuzumab-based chemotherapy improves survival in HER2-positive advanced gastric cancer, some patients demonstrate suboptimal efficacy and limited response durations. We examined the relationship between clinical outcomes and genomic features, including co-mutations and the length of the <italic>ERBB2</italic>-amplified segment. Methods We retrospectively analyzed 151...

Topics

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• Carcinoma
• Gene Expression Regulation, Neoplastic
• Genomic Instability
• Glycosylation and Glycoproteins Research
• High-Throughput Nucleotide Sequencing
• Molecular Targeted Therapy
• Monoclonal and Polyclonal Antibodies Research
• Stomach Neoplasms

Identifiers and source

Literature Corpus work

63985968-6ece-5544-b356-dcbe0f8d1b0e

DOI

10.21203/rs.3.rs-7267337/v1