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Article

DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E in vitro.

Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2014

Coupland Kirsten G, Mellick George D, Silburn Peter A, Mather Karen, Armstrong Nicola J, Sachdev Perminder S, Brodaty Henry, Huang Yue, Halliday Glenda M, Hallupp Marianne, Kim Woojin S, Dobson-Stone Carol, Kwok John B J

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder for which environmental factors influence disease risk and may act via an epigenetic mechanism. The microtubule-associated protein tau (MAPT) is a susceptibility gene for idiopathic PD. Methylation levels were determined by pyrosequencing of bisulfite-treated DNA in a leukocyte cohort (358 PD patients and 1084 controls) and in two brain cohorts (Brain1,...

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Identifiers

PMID: 24375821
DOI: 10.1002/mds.25784
PMCID: PMC4074263

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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