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Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos

9 Jul 2025

Abstract excerpt

Introduction Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and tremor. Despite its prevalence, genetic and epigenetic studies in the Mexican Mestizo population (individuals of mixed Indigenous and European—primarily Spanish—ancestry who represent the majority demographic in Mexico) remain limited. DNA methylation may play a role in PD...

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PMID: 40703677
DOI: 10.3389/fnagi.2025.1612544

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