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Article

Molecular docking investigation of the binding interactions of macrocyclic inhibitors with HCV NS3 protease and its mutants (R155K, D168A and A156V).

The protein journal - 1 Feb 2014

Ezat Ahmed A, El-Bialy Nihal S, Mostafa Hamdy I A, Ibrahim Medhat A

Abstract excerpt

Hepatitis C Virus (HCV) non-structural protein 3 (NS3) protease drug resistance poses serious challenges on the design of an effective treatment. Substrate Envelope Hypothesis, "the substrates of HCV NS3/4A protease have a consensus volume inside the active site called substrate envelope" is used to design potent and specific drugs to overcome this problem. Using molecular docking, we studied the binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24374429
DOI: 10.1007/s10930-013-9538-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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