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Article

Molecular modeling study on the drug resistance mechanism of NS5B polymerase to TMC647055.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Apr 2016

Wang Huiqun, Cui Wei, Guo Chenchen, Chen Bo-Zhen, Ji Mingjuan

Abstract excerpt

NS5B polymerase plays an important role in viral replication machinery. TMC647055 (TMC) is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase. However, mutations that result in drug resistance to TMC have been reported. In this study, we used molecular dynamics (MD) simulations, binding free energy calculations, and free energy decomposition to investigate the drug resistance mechanism of HCV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26836778
DOI: 10.1139/bcb-2015-0109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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