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Article

Exploring the Drug Resistance of HCV Protease.

The journal of physical chemistry. B - 20 Jul 2017

Jindal Garima, Mondal Dibyendu, Warshel Arieh

Abstract excerpt

Hepatitis C virus (HCV) currently affects several million people across the globe. One of the major classes of drugs against HCV inhibits the NS3/4A protease of the polyprotein chain. Efficacy of these drugs is severely limited due to the high mutation rate that results in several genetically related quasispecies. The molecular mechanism of drug resistance is frequently deduced from structural studies and binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28635289
DOI: 10.1021/acs.jpcb.7b04562
PMCID: PMC6237193

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