Article
High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii.
Microbial cell factories - 28 Jan 2016
Maervoet Veerle E T, De Maeseneire Sofie L, Avci Fatma G, Beauprez Joeri, Soetaert Wim K, De Mey Marjan
Abstract excerpt
BACKGROUND: Imbalance in cofactors causing the accumulation of intermediates in biosynthesis pathways is a frequently occurring problem in metabolic engineering when optimizing a production pathway in a microorganism. In our previous study, a single knock-out Citrobacter werkmanii ∆dhaD was constructed for improved 1,3-propanediol (PDO) production. Instead of an enhanced PDO concentration on this strain, the gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.