Article
Using multiple methods to characterize the phenotype of individuals with a family history of major depressive disorder.
Journal of affective disorders - 5 Sept 2013
Watters Anna J, Gotlib Ian H, Harris Anthony W F, Boyce Philip M, Williams Leanne M
Abstract excerpt
BACKGROUND: Unaffected relatives (URs) of individuals with major depressive disorder (MDD) are biologically more vulnerable to depression. We compare healthy URs and controls at the level of phenotype (symptoms and functioning) and endophenotype (negative emotion bias), and further investigate the interrelation between these and the contribution of environmental early life stress. METHODS: URs (n=101), identified...
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