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Article

The MTHFD1 1958G>A variant is associated with elevated C-reactive protein and body mass index in Canadian women from a premature birth cohort.

Molecular genetics and metabolism - 1 Mar 2014

Christensen Karen E, Dahhou Mourad, Kramer Michael S, Rozen Rima

Abstract excerpt

MTHFD1 1958G>A, a polymorphism in folate metabolism, increases risk of pregnancy complications. A mouse model exhibited developmental defects, increased weight and decreased leukocyte counts. To examine the latter associations, we genotyped 651 women from a premature birth cohort. Prematurity and 1958G>A were not associated. Increases in the inflammatory marker CRP (logistic regression, p = 0.055) and BMI...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24368157
DOI: 10.1016/j.ymgme.2013.12.004

Genes

MTHFD1
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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