Article
Promoter methylation status of MGMT, hMSH2, and hMLH1 and its relationship to corresponding protein expression and TP53 mutations in human esophageal squamous cell carcinoma.
Medical oncology (Northwood, London, England) - 1 Feb 2014
Su Yaoyao, Yin Lihong, Liu Ran, Sheng Jingyi, Yang Miao, Wang Yi, Pan Enchun, Guo Wei, Pu Yuepu, Zhang Juan, Liang Geyu
Abstract excerpt
To determine the relevance of O-6-methylguanine-DNA methyltransferase (MGMT), human mutS homolog 2 (hMSH2), and human mutL homolog 1 (hMLH1) in TP53 mutations in esophageal squamous cell carcinoma, we employed methylation-sensitive high-resolution melting technology and methylation-specific polymerase chain reaction (PCR) to analyze promoter hypermethylation of MGMT, hMSH2, and hMLH1, respectively, in 51 paired...
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