Article
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira.
Frontiers in cellular and infection microbiology - 1 Jan 2018
Adhikarla Haritha, Wunder Elsio A, Mechaly Ariel E, Mehta Sameet, Wang Zheng, Santos Luciane, Bisht Vimla, Diggle Peter, Murray Gerald, Adler Ben, Lopez Francesc, Townsend Jeffrey P, Groisman Eduardo, Picardeau Mathieu, Buschiazzo Alejandro, Ko Albert I
Abstract excerpt
Leptospirosis is an emerging zoonotic disease with more than 1 million cases annually. Currently there is lack of evidence for signaling pathways involved during the infection process of Leptospira. In our comprehensive genomic analysis of 20 Leptospira spp. we identified seven pathogen-specific Two-Component System (TCS) proteins. Disruption of two these TCS genes in pathogenic Leptospira strain resulted in...
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