Article
Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes.
Journal of diabetes and its complications - 1 Jan 2000
Wang Ying, Luk Andrea O Y, Ng Maggie C Y, Pang Calvin C P, Lam Vincent, Lee Shao C, Lam Dennis S C, Choy Kwong Wai, Ma Ronald C W, So Wing-Yee, Chan Juliana C N
Abstract excerpt
AIMS: To examine the additive effect of the z-4 microsatellite polymorphism of aldose reductase gene (ALR2) and glycaemic control on risk of cataract in a prospective cohort of Chinese type 2 diabetic patients. METHODS: The (CA)n microsatellite polymorphism of ALR2 was determined using PCR followed by capillary gel electrophoresis. Cataract was defined by presence of lens opacity on direct ophthalmoscopy or...
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