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Article

Rab18 inhibits secretory activity in neuroendocrine cells by interacting with secretory granules.

Traffic (Copenhagen, Denmark) - 1 Jul 2007

Vazquez-Martinez Rafael, Cruz-Garcia David, Duran-Prado Mario, Peinado Juan R, Castaño Justo P, Malagon Maria M

Abstract excerpt

Rab proteins comprise a complex family of small GTPases involved in the regulation of intracellular membrane trafficking and reorganization. In this study, we identified Rab18 as a new inhibitory player of the secretory pathway in neuroendocrine cells. In adrenal chromaffin PC12 cells and pituitary AtT20 cells, Rab18 is located at the cytosol but associates with a subpopulation of secretory granules after...

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Identifiers

PMID: 17488286
DOI: 10.1111/j.1600-0854.2007.00570.x

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