Article
Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR.
PloS one - 1 Jan 2013
El Meouche Imane, Peltier Johann, Monot Marc, Soutourina Olga, Pestel-Caron Martine, Dupuy Bruno, Pons Jean-Louis
Abstract excerpt
Clostridium difficile intestinal disease is mediated largely by the actions of toxins A (TcdA) and B (TcdB), whose production occurs after the initial steps of colonization involving different surface or flagellar proteins. In B. subtilis, the sigma factor SigD controls flagellar synthesis, motility, and vegetative autolysins. A homolog of SigD encoding gene is present in the C.difficile 630 genome. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.