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Article

A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy.

Physiological research - 1 Jan 2011

Hubáček J A, Pelikánová T, Lánská V, Komers R

Abstract excerpt

Diabetic nephropathy (DN), the most serious complication of Type 1 diabetes (DM1), has a strong genetic component. Cyclooxygenase-2 (COX-2), an inducible enzyme by a number of stimuli, has been implicated in pathophysiology of cardiovascular and renal disease, including DN. The allele -765C, of the -765G > C polymorphism (rs20417) in the COX-2 promoter has lower promoter activity compared with the -765G allele...

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Identifiers

PMID: 21114363
DOI: 10.33549/physiolres.932016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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