Article
Candidate's single-nucleotide polymorphism predictors of treatment nonresponse to the first anti-TNF inhibitor in ankylosing spondylitis.
Rheumatology international - 1 Jun 2014
Schiotis Ruxandra, Sánchez Alejandra, Escudero Alejandro, Bartolomé Nerea, Szczypiorska Magdalena, Font Pilar, Martínez Antonio, Tejedor Diego, Artieda Marta, Mulero Juan, Buzoianu Anca, Collantes-Estévez Eduardo
Abstract excerpt
The objective of this study is to identify single-nucleotide polymorphisms (SNPs) predictors of treatment nonresponse to the first anti-TNF-alpha agent in ankylosing spondylitis (AS). Patients were classified as "nonresponders" if they failed to achieve improvement ≥50 % of the initial BASDAI. We selected candidate SNPs previously reported, associated with susceptibility or pathogenesis of AS and with other...
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