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Article

Role of topoisomerase I and thymidylate synthase expression in sporadic colorectal cancer: associations with clinicopathological and molecular features.

Pathology, research and practice - 1 Feb 2014

Azzoni Cinzia, Bottarelli Lorena, Cecchini Stefano, Ziccarelli Antonio, Campanini Nicoletta, Bordi Cesare, Sarli Leopoldo, Silini Enrico Maria

Abstract excerpt

Topoisomerase I (Topo I) and thymidylate synthase (TS) are essential enzymes for the replication, transcription and repair of DNA, and are potential biomarkers in colorectal cancer (CRC). The aim of the study was to correlate the tissue expression of Topo I and TS in sporadic CRCs with relevant pathological and molecular features and patients' outcome. Topo I and TS expression was assessed by immunostaining in...

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Identifiers

PMID: 24332575
DOI: 10.1016/j.prp.2013.11.004

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