Article
Abnormal tyrosine phosphorylation on T-cell receptor in lymphoproliferative disorders.
Nature - 1 Jan 2000
Samelson L E, Davidson W F, Morse H C, Klausner R D
Abstract excerpt
The study of human autoimmune diseases has benefited greatly from analysis of animal models. Mice that are homozygous for either the lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) mutant genes develop a disease characterized by massive lymphadenopathy and autoantibody formation. With age, the lymphoid organs in these mice are replaced with a greatly expanded population of abnormal...
Topics
- Amino Acids
- Animals
- Lymphoproliferative Disorders
- Macromolecular Substances
- Mice
- Mice, Mutant Strains
- Mutation
- Phosphorylation
- Phosphotyrosine
- Receptors, Antigen, T-Cell
- Tyrosine