Article
Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles.
BMC genomics - 9 Dec 2013
Dharuri Harish, Henneman Peter, Demirkan Ayse, van Klinken Jan Bert, Mook-Kanamori Dennis Owen, Wang-Sattler Rui, Gieger Christian, Adamski Jerzy, Hettne Kristina, Roos Marco, Suhre Karsten, Van Duijn Cornelia M, van Dijk Ko Willems, 't Hoen Peter A C
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest effect sizes. In contrast, SNPs that associate with metabolite levels generally explain a higher percentage of the genetic variation and demonstrate larger...
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