Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.

Molecular pharmacology - 1 Apr 2010

Li Ping, Khatri Alpa, Bracamontes John, Weiss David S, Steinbach Joe Henry, Akk Gustav

Abstract excerpt

The rho 1 GABA receptor is inhibited by a number of neuroactive steroids. A previous study (J Pharmacol Exp Ther 323:236-247, 2007) focusing on the electrophysiological effects of inhibitory steroids on the rho 1 receptor found that steroid inhibitors could be divided into three major groups base...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to Estradiol
Share to Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gamma-Aminobutyric Acid

Share to Mutation

Share to Neurotransmitter Agents

Share to Protein Conformation

Share to Receptors, GABA-B

Source

Open in PubMed Open full text

Identifiers

PMID: 20061447
DOI: 10.1124/mol.109.062885
PMCID: PMC2845946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20061447-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.PMID 20061447Read ↗

Modulation of the human ρ1 GABAA receptor by inhibitory steroids.Semantic proximity Read ↗

Neuroactive steroids and human recombinant rho1 GABAC receptors.Semantic proximity Read ↗

A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism.Semantic proximity Read ↗

Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity.Semantic proximity Read ↗

Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors.Semantic proximity Read ↗

Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening.Semantic proximity Read ↗

Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses.Semantic proximity Read ↗

A single amino acid in the second transmembrane domain of GABA rho receptors regulates channel conductance.Semantic proximity Read ↗

The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin.Semantic proximity Read ↗

Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors.Semantic proximity Read ↗

Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.Semantic proximity Read ↗

[GABAC receptors: structure and functions].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.