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Article

Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.

Molecular pharmacology - 1 Apr 2010

Li Ping, Khatri Alpa, Bracamontes John, Weiss David S, Steinbach Joe Henry, Akk Gustav

Abstract excerpt

The rho 1 GABA receptor is inhibited by a number of neuroactive steroids. A previous study (J Pharmacol Exp Ther 323:236-247, 2007) focusing on the electrophysiological effects of inhibitory steroids on the rho 1 receptor found that steroid inhibitors could be divided into three major groups based on how mutations to residues in the M2 transmembrane domain modified inhibition. It was proposed that the steroids...

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Identifiers

PMID: 20061447
DOI: 10.1124/mol.109.062885
PMCID: PMC2845946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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