Degree of methylation of<i>ZAC1</i>(<i>PLAGL1</i>) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort

Abstract excerpt

The ZAC1 gene, mapped to the 6q24 region, is part of a network of co-regulated imprinted genes involved in the control of embryonic growth. Loss of methylation at the ZAC1 differentially methylated region (DMR) is associated with transient neonatal diabetes mellitus, a developmental disorder involving growth retardation and diabetes in the first weeks of post-natal life. We assessed whether the degree of...

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