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Article

Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta

3 Jul 2014

Abstract excerpt

Genomic imprinting is the epigenetic process that results in monoallelic expression of genes depending on parental origin. These genes are known to be critical for placental development and fetal growth in mammals. Aberrant epigenetic profiles at imprinted loci, such as DNA methylation defects, are surprisingly rare in pregnancies with compromised fetal growth, while variations in transcriptional output from the...

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Share to Epigenetics and DNA Methylation
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PMID: 24993786
DOI: 10.1093/hmg/ddu347

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