Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ELABELA: a hormone essential for heart development signals via the apelin receptor.

Developmental cell - 23 Dec 2013

Chng Serene C, Ho Lena, Tian Jing, Reversade Bruno

Abstract excerpt

We report here the discovery and characterization of a gene, ELABELA (ELA), encoding a conserved hormone of 32 amino acids. Present in human embryonic stem cells, ELA is expressed at the onset of zebrafish zygotic transcription and is ubiquitous in the naive ectodermal cells of the embryo. Using zinc-finger-nuclease-mediated gene inactivation in zebrafish, we created an allelic series of ela mutants. ela null...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Embryo, Nonmammalian
Share to Endoderm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Hormones

Share to Receptors, G-Protein-Coupled

Share to Zebrafish Proteins

Share to Zinc Fingers

Source

Identifiers

PMID: 24316148
DOI: 10.1016/j.devcel.2013.11.002

Genes

APLNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ELABELA: a hormone essential for heart development signals via the apelin receptor.PMID 24316148Read ↗

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.Semantic proximity Read ↗

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in miceSemantic proximity Read ↗

Loss-of-function of Endothelin receptor type A results in Oro-Oto-Cardiac syndrome.Semantic proximity Read ↗

An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbiditiesSemantic proximity Read ↗

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.Semantic proximity Read ↗

Understanding the basis of auriculocondylar syndrome: Insights from human, mouse and zebrafish genetic studiesSemantic proximity Read ↗

Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish.Semantic proximity Read ↗

Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis GenesSemantic proximity Read ↗

Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.Semantic proximity Read ↗

Endothelin signaling in developmentSemantic proximity Read ↗

Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptorSemantic proximity Read ↗

Apelin signaling drives vascular endothelial cells toward a pro-angiogenic stateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.