Article
Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence.
Biological psychiatry - 15 May 2014
Jorde Anne, Bach Patrick, Witt Stephanie H, Becker Kathleen, Reinhard Iris, Vollstädt-Klein Sabine, Kirsch Martina, Hermann Derik, Charlet Katrin, Beck Anne, Wimmer Lioba, Frank Josef, Treutlein Jens, Spanagel Rainer, Mann Karl, Walter Henrik, Heinz Andreas, Rietschel Marcella, Kiefer Falk
Abstract excerpt
BACKGROUND: Two genome-wide association studies recently showed alcohol dependence to be associated with a single-nucleotide polymorphism (rs13273672) located on a gene (GATA4) that encodes a transcription factor of atrial natriuretic peptide (ANP). A growing body of evidence suggests that ANP mi...
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