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Article

[CD38 and autism spectrum disorders].

No to hattatsu = Brain and development - 1 Nov 2013

Higashida Haruhiro, Munesue Toshio

Abstract excerpt

We have demonstrated that CD38, a transmembrane protein with ADP-ribosyl cyclase activity, plays a critical role in mouse social behavior by regulating the release of oxytocin (OXT), which is essential for mutual recognition. When CD38 was disrupted, social amnesia was observed in Cd38 knockout mice. We investigated single nucleotide polymorphisms (SNPs) in the human CD38 gene in autism spectrum disorder (ASD)...

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Share to ADP-ribosyl Cyclase 1
Share to Child Development Disorders, Pervasive
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oxytocin

Share to Polymorphism, Single Nucleotide

Share to Social Behavior

Source

Identifiers

PMID: 24313001

Genes

OXT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[CD38 and autism spectrum disorders].PMID 24313001Read ↗

Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38.Semantic proximity Read ↗

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Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study.Semantic proximity Read ↗

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Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes.Semantic proximity Read ↗

Effects of a common variant in the CD38 gene on social processing in an oxytocin challenge study: possible links to autism.Semantic proximity Read ↗

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior.Semantic proximity Read ↗

Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder.Semantic proximity Read ↗

All-trans retinoic acid upregulates reduced CD38 transcription in lymphoblastoid cell lines from Autism spectrum disorder.Semantic proximity Read ↗

The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis.Semantic proximity Read ↗

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