Article
All-trans retinoic acid upregulates reduced CD38 transcription in lymphoblastoid cell lines from Autism spectrum disorder.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2011
Riebold Mathias, Mankuta David, Lerer Elad, Israel Salomon, Zhong Songfa, Nemanov Luba, Monakhov Mikhail V, Levi Shlomit, Yirmiya Nurit, Yaari Maya, Malavasi Fabio, Ebstein Richard P
Abstract excerpt
Deficits in social behavior in mice lacking the CD38 gene have been attributed to impaired secretion of oxytocin. In humans, similar deficits in social behavior are associated with autistic spectrum disorder (ASD), for which genetic variants of CD38 have been pinpointed as provisional risk factors. We sought to explore, in an in vitro model, the feasibility of the theory that restoring the level of CD38 in ASD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.