Article
Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38.
Neurochemistry international - 1 Nov 2012
Higashida Haruhiro, Yokoyama Shigeru, Huang Jian-Jun, Liu Li, Ma Wen-Jie, Akther Shirin, Higashida Chiharu, Kikuchi Mitsuru, Minabe Yoshio, Munesue Toshio
Abstract excerpt
Previously, we demonstrated that CD38, a transmembrane protein with ADP-ribosyl cyclase activity, plays a critical role in mouse social behavior by regulating the release of oxytocin (OXT), which is essential for mutual recognition. When CD38 was disrupted, social amnesia was observed in Cd38 knockout mice. The autism spectrum disorders (ASDs), characterized by defects in reciprocal social interaction and...
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