Article
Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study.
Autism research : official journal of the International Society for Autism Research - 1 Dec 2010
Lerer Elad, Levi Shlomit, Israel Salomon, Yaari Maya, Nemanov Lubov, Mankuta David, Nurit Yirmiya, Ebstein Richard P
Abstract excerpt
BACKGROUND: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion....
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