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Article

CD38 and its role in oxytocin secretion and social behavior.

Hormones and behavior - 1 Mar 2012

Higashida Haruhiro, Yokoyama Shigeru, Kikuchi Mitsuru, Munesue Toshio

Abstract excerpt

Here, we review the functional roles of cyclic ADP-ribose and CD38, a transmembrane protein with ADP-ribosyl cyclase activity, in mouse social behavior via the regulation of oxytocin (OXT) release, an essential component of social cognition. Herein we describe data detailing the molecular mechanism of CD38-dependent OXT secretion in CD38 knockout mice. We also review studies that used OXT, OXT receptor (OXTR), or...

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Source

Identifiers

PMID: 22227279
DOI: 10.1016/j.yhbeh.2011.12.011

Genes

OXT
OXTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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