Article
Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style.
The British journal of psychiatry : the journal of mental science - 1 Feb 2014
Rose Emma Jane, Hargreaves April, Morris Derek, Fahey Ciara, Tropea Daniela, Cummings Elizabeth, Caltagirone Carlo, Bossù Paola, Chiapponi Chiara, Piras Fabrizio, Spalletta Gianfranco, Gill Michael, Corvin Aiden, Donohoe Gary
Abstract excerpt
BACKGROUND: A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown. AIMS: To determine the impact of the rs7914558 risk 'G' allele [corrected] on measures of neurocognition, social cognition and brain structure. METHOD: Patients with schizophrenia (n = 400) and healthy...
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