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Article

The Role of Extent of Resection in IDH1 Wild-Type or Mutant Low-Grade Gliomas.

Neurosurgery - 1 Jun 2018

Patel Toral, Bander Evan D, Venn Rachael A, Powell Tiffany, Cederquist Gustav Young-Min, Schaefer Peter M, Puchi Luis A, Akhmerov Akbarshakh, Ogilvie Shahiba, Reiner Anne S, Moussazadeh Nelson, Tabar Viviane

Abstract excerpt

BACKGROUND: Maximizing extent of resection (EOR) improves outcomes in adults with World Health Organization (WHO) grade II low-grade gliomas (LGG). However, recent studies demonstrate that LGGs bearing a mutation in the isocitrate dehydrogenase 1 (IDH1) gene are a distinct molecular and clinical entity. It remains unclear whether maximizing EOR confers an equivalent clinical benefit in IDH mutated (mtIDH) and IDH...

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Identifiers

PMID: 28945860
DOI: 10.1093/neuros/nyx265
PMCID: PMC7571505

Genes

IDH1

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