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Article

Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry.

Neuro-oncology - 1 Mar 2014

Tran Anh N, Lai Albert, Li Sichen, Pope Whitney B, Teixeira Stephanie, Harris Robert J, Woodworth Davis C, Nghiemphu Phioanh L, Cloughesy Timothy F, Ellingson Benjamin M

Abstract excerpt

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutations have been linked to favorable outcomes in patients with glioblastoma multiforme (GBM). Recent in vitro experiments suggest that IDH1 mutation sensitizes tumors to radiation damage. We hypothesized that radiographic treatment response would be significantly different between IDH1 mutant versus wild-type GBMs after radiotherapy (RT) and concurrent temozolomide...

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Source

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Identifiers

PMID: 24305712
DOI: 10.1093/neuonc/not198
PMCID: PMC3922511

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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