Article
Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women.
Genetics and molecular research : GMR - 18 Nov 2013
Gómez Flores-Ramos L, Escoto-De Dios A, Puebla-Pérez A M, Figuera-Villanueva L E, Ramos-Silva A, Ramírez-Patiño R, Delgado-Saucedo J I, Salas-González E, Zúñiga-González G M, Alonzo-Rojo A, Gutiérrez-Hurtado I, Gallegos-Arreola M P
Abstract excerpt
The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with those of 465 Mexican women with breast...
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