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Article

Alterations of insulin-like growth factor-1 receptor gene copy number and protein expression are common in non-small cell lung cancer

12 Aug 2014

Abstract excerpt

AIMS: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase membrane receptor involved in tumourigenesis that may be a potential therapeutic target. We aimed to investigate the incidence and prognostic significance of alterations in IGF1R copy number, and IGF1R protein expression in resected primary non-small cell lung cancer (NSCLC), and lymph node metastases. METHODS: IGF1R gene copy number status...

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Share to Genomic variations and chromosomal abnormalities
Share to Growth Hormone and Insulin-like Growth Factors
Share to Lung Cancer Treatments and Mutations

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PMID: 25118293
DOI: 10.1136/jclinpath-2014-202347

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