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Article

Characterization of virus-like particles in GARDASIL® by cryo transmission electron microscopy

3 Dec 2013

Abstract excerpt

Cryo-transmission electron microscopy (cryoTEM) is a powerful characterization method for assessing the structural properties of biopharmaceutical nanoparticles, including Virus Like Particle-based vaccines. We demonstrate the method using the Human Papilloma Virus (HPV) VLPs in GARDASIL®. CryoTEM, coupled to automated data collection and analysis, was used to acquire images of the particles in their hydrated...

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PMID: 24299977
DOI: 10.4161/hv.27316

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