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Article

Investigation of CTLA-4 and CD86 gene polymorphisms in Iranian patients with brucellosis infection.

Microbiology and immunology - 1 Feb 2014

Eskandari-Nasab Ebrahim, Moghadampour Mehdi, Najibi Habib, Hadadi-Fishani Mehdi

Abstract excerpt

The protective immune response against Brucella involves T-cell-mediated immunity. T-lymphocyte receptors, CD28 and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), bind the same ligands, CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells and regulate T cell activation. CD28 delivers stimulatory signals whereas CTLA-4 provides inhibitory signals for T cell activation. Here, we investigated the...

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Source

Identifiers

PMID: 24298899
DOI: 10.1111/1348-0421.12119

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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